ARNTL CLIA Kit for Human(Homo sapiens) | EIAab.comARNTL CLIA Kit for Human(Homo sapiens)

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ARNTL (Gene name),

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Protein name ), BMAL1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

ARNTL(BHLHE5;BMAL1;MOP3;PASD3);

Protein name:

Aryl hydrocarbon receptor nuclear translocator-like protein 1;

Alternative:

Brain and muscle ARNT-like 1;Basic-helix-loop-helix-PAS protein MOP3;Member of PAS protein 3;Class E basic helix-loop-helix protein 5(bHLHe5);bHLH-PAS protein JAP3;PAS domain-containing protein 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo. Part of a nuclear complex which also includes GNB2L1/RACK1 and PRKCA; GNB2L1 and PRKCA are recruited to the complex in a circadian manner.

Function:

ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

626

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

626:

AVIMSLLEAD | AGLGGPVDFS | DLPWPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O00327

MIM:

602550

UniGene:

Hs.65734

KEGG:

hsa:406

Pfam:

PF00010

SMR:

O00327

Uniprot:

O00327

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ELISA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

E10272h

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96T

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ELISA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

E10272c

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96T

ELISA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

E10272r

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96T

ELISA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

E10272m

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96T

CLIA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

U10272h

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Packing:

96T

CLIA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

U10272c

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MSDS:

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Packing:

96T

CLIA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

U10272m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

U10272r

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96T

Polyclonal Antibody for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

P10272Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

P10272Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

P10272Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

Protein for Human Aryl hydrocarbon receptor nuclear translocator-like protein 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage."
Ikeda M. , Nomura M.
Biochem. Biophys. Res. Commun.233:258-264(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];ALTERNATIVE SPLICING (ISOFORMS BMAL1A; BMAL1B; BMAL1C; BMAL1D; BMAL1E AND BMAL1F)
tissue: Brain.
2.

"Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."
Hogenesch J.B. , Chan W.K. , Jackiw V.H. , Brown R.C. , Gu Y.-Z. , Pray-Grant M. , Perdew G.H. , Bradfield C.A.
J. Biol. Chem.272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MOP3);INTERACTION WITH HSP90 AND AHR
tissue: Fetal brain.
3.

"JAP3: a novel ARNT-like bHLH-PAS protein."
Tian H. , Russell D.W. , McKnight S.L.
Submitted (1996-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BMAL1B)
4.

"The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors."
Hogenesch J.B. , Gu Y.Z. , Jain S. , Bradfield C.A.
Proc. Natl. Acad. Sci. U.S.A.95:5474-5479(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BMAL1B)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS BMAL1B AND 9)
tissue: Brain.
6.

"ARNTL resequence."
Kripke D.F. , Klimecki W.
Submitted (2006-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 8 AND BMAL1A)
tissue: Brain.
tissue: Skin.
10.

"Role of the CLOCK protein in the mammalian circadian mechanism."
Gekakis N. , Staknis D. , Nguyen H.B. , Davis F.C. , Wilsbacher L.D. , King D.P. , Takahashi J.S. , Weitz C.J.
Science280:1564-1569(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLOCK
11.

"Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."
Rutter J. , Reick M. , Wu L.C. , McKnight S.L.
Science293:510-514(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;ENZYME REGULATION
12.

"Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2."
Schoenhard J.A. , Smith L.H. , Painter C.A. , Eren M. , Johnson C.H. , Vaughan D.E.
J. Mol. Cell. Cardiol.35:473-481(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
Curtis A.M. , Seo S.B. , Westgate E.J. , Rudic R.D. , Smyth E.M. , Chakravarti D. , FitzGerald G.A. , McNamara P.
J. Biol. Chem.279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAT2B AND EP300
14.

"Feedback repression is required for mammalian circadian clock function."
Sato T.K. , Yamada R.G. , Ukai H. , Baggs J.E. , Miraglia L.J. , Kobayashi T.J. , Welsh D.K. , Kay S.A. , Ueda H.R. , Hogenesch J.B.
Nat. Genet.38:312-319(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-9; SER-10; ALA-611 AND GLY-612
15.

"CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter."
Li R. , Yue J. , Zhang Y. , Zhou L. , Hao W. , Yuan J. , Qiang B. , Ding J.M. , Peng X. , Cao J.M.
Mol. Cell. Biochem.317:169-177(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock."
DiTacchio L. , Le H.D. , Vollmers C. , Hatori M. , Witcher M. , Secombe J. , Panda S.
Science333:1881-1885(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDM5A
17.

"Mechanism of the circadian clock in physiology."
Richards J. , Gumz M.L.
Am. J. Physiol.304:R1053-R1064(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth."
Watabe Y. , Tomioka M. , Watabe A. , Aihara M. , Shimba S. , Inoue H.
Arch. Dermatol. Res.305:755-761(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
Baeza-Raja B. , Eckel-Mahan K. , Zhang L. , Vagena E. , Tsigelny I.F. , Sassone-Corsi P. , Ptacek L.J. , Akassoglou K.
J. Neurosci.33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Metabolism and the circadian clock converge."
Eckel-Mahan K. , Sassone-Corsi P.
Physiol. Rev.93:107-135(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
21.

"Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression."
Annayev Y. , Adar S. , Chiou Y.Y. , Lieb J. , Sancar A. , Ye R.
J. Biol. Chem.289:5013-5024(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CIART
22.

"A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock."
Al-Nuaimi Y. , Hardman J.A. , Biro T. , Haslam I.S. , Philpott M.P. , Toth B.I. , Farjo N. , Farjo B. , Baier G. , Watson R.E. , Grimaldi B. , Kloepper J.E. , Paus R.
J. Invest. Dermatol.134:610-619(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HAIR GROWTH;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
23.

"The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor."
Gossan N.C. , Zhang F. , Guo B. , Jin D. , Yoshitane H. , Yao A. , Glossop N. , Zhang Y.Q. , Fukada Y. , Meng Q.J.
Nucleic Acids Res.42:5765-5775(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE3A
24.

"Molecular architecture of the mammalian circadian clock."
Partch C.L. , Green C.B. , Takahashi J.S.
Trends Cell Biol.24:90-99(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW

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